Synthesis of novel coumarin and benzocoumarin ...
|Title||Synthesis of novel coumarin and benzocoumarin derivatives and their biological and photophysical studies.|
|Author(s)||A. Abd-El-Aziz, H. Mohamed, S. Mohammed, S. Zahid, A. Ata, A. Bedair, A. El-Agrody, P. Harvey|
|Journal||Section Title: Heterocyclic Compounds (One Hetero Atom), Journal of Heterocyclic Chemistry|
|Abstract||Several derivs. of coumarin-3N-carboxamides have been prepd. via the reaction of the coumarin-3-carbonyl chloride with a no. of nucleophiles. Novel double-headed coumarin-3N-carboxamides were also produced using the same method. The Pechmann-Duisberg reaction was applied to prep. new benzo[f]- benzo[h]coumarins and 4-(chloromethyl)-pyrano[3,2-c]coumarin-2-one. The reaction of 1-chloromethylbenzo[f]coumarins with cyanide anion under different reaction conditions was also investigated in order to assess its suitability for nucleophilic substitution reactions as well as ring transformation products. Synthesis of 1-((benzo[d]thiazol-2-yl)methyl)-9-hydroxybenzo[f]coumarin represented the first example of methylene bridge-head heterocycle-contg. benzo[f]coumarin. Some of the newly prepd. coumarins exhibited anti-bacterial activity against Gram Pos. and Gram neg. bacteria. Compd. I was found to be active against all the screened bacteria. Photophys. studies were performed on selected fluorescent benzo[f]- and benzo[h]coumarins and the quantum yields were also calcd. All new compds. were characterized by IR, MS, 1H and 13C NMR, as well as elemental anal. [on SciFinder(R)]|
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