The pro-apoptotic protein Bim is a microRNA target ...



Title The pro-apoptotic protein Bim is a microRNA target in kidney progenitors
Author(s) Jacqueline Ho, Priyanka Pandey, Tobias Schatton, Sunder Sims-Lucas, Myda Khalid, Markus H. Frank, Sunny Hartwig, Jordan A. Kreidberg
Journal Journal of the American Society of Nephrology: JASN
Date 2011
Volume 22
Issue 6
Start page 1053
End page 1063
Abstract Understanding the mechanisms that regulate nephron progenitors during kidney development should aid development of therapies for renal failure. MicroRNAs, which modulate gene expression through post-transcriptional repression of specific target mRNAs, contribute to the differentiation of stem cells, but their role in nephrogenesis is incompletely understood. Here, we found that the loss of miRNAs in nephron progenitors results in a premature depletion of this population during kidney development. Increased apoptosis and expression of the pro-apoptotic protein Bim accompanied this depletion. Profiling of miRNA expression during nephrogenesis identified several highly expressed miRNAs (miR-10a, miR-106b, miR-17-5p) in nephron progenitors that are either known or predicted to target Bim. We propose that modulation of apoptosis by miRNAs may determine congenital nephron endowment. Furthermore, our data implicate the pro-apoptotic protein Bim as a miRNA target in nephron progenitors.
DOI 10.1681/asn.2010080841

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