Aquareovirus effects syncytiogenesis by using a ...

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Title Aquareovirus effects syncytiogenesis by using a novel member of the FAST protein family translated from a noncanonical translation start site
Author(s) Trina Racine, Tara Hurst, Chris Barry, Jingyun Shou, Frederick Kibenge, Roy Duncan
Journal Journal of Virology
Date 2009
Volume 83
Issue 11
Start page 5951
End page 5955
Abstract As nonenveloped viruses, the aquareoviruses and orthoreoviruses are unusual in their ability to induce cell-cell fusion and syncytium formation. While an extraordinary family of fusion-associated small transmembrane (FAST) proteins is responsible for orthoreovirus syncytiogenesis, the basis for aquareovirus-induced syncytiogenesis is unknown. We now report that the S7 genome segment of an Atlantic salmon reovirus is polycistronic and uses a noncanonical CUG translation start codon to produce a 22-kDa integral membrane protein responsible for syncytiogenesis. The aquareovirus p22 protein represents a fourth distinct member of the FAST family with a unique repertoire and arrangement of structural motifs.
DOI 10.1128/jvi.00171-09

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