Aquareovirus effects syncytiogenesis by using a ...
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Citation
| Title | Aquareovirus effects syncytiogenesis by using a novel member of the FAST protein family translated from a noncanonical translation start site |
| Author(s) | T. Racine, T. Hurst, C. Barry, J. Shou, F. Kibenge, R. Duncan |
| Journal | Journal of Virology |
| Date | 2009 |
| Volume | 83 |
| Issue | 11 |
| Start page | 5951 |
| End page | 5955 |
| Abstract | As nonenveloped viruses, the aquareoviruses and orthoreoviruses are unusual in their ability to induce cell-cell fusion and syncytium formation. While an extraordinary family of fusion-associated small transmembrane (FAST) proteins is responsible for orthoreovirus syncytiogenesis, the basis for aquareovirus-induced syncytiogenesis is unknown. We now report that the S7 genome segment of an Atlantic salmon reovirus is polycistronic and uses a noncanonical CUG translation start codon to produce a 22-kDa integral membrane protein responsible for syncytiogenesis. The aquareovirus p22 protein represents a fourth distinct member of the FAST family with a unique repertoire and arrangement of structural motifs. |
| ISSN | 1098-5514 |
Using APA 6th Edition citation style.
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