Isolation, biomimetic synthesis, and cytotoxic ...

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Title Isolation, biomimetic synthesis, and cytotoxic activity of bis(pseudopterane) amines
Author(s) A. S. Kate, J. K. Pearson, B. Ramanathan, K. Richard, R. G. Kerr
Journal Journal of Natural Products
Date 2009
Volume 72
Issue 7
Start page 1331
End page 1334
Abstract LC-MS/MS-based screening of the dichloromethane extract of the gorgonian coral Pseudopterogorgia acerosa led to the isolation of a novel bis(pseudopterane) amine (1). The structural assignment of 1 was achieved by 1D and 2D NMR and mass spectrometry analysis. A biomimetic synthesis of 1 and the known symmetrical diterpene 2 from pseudopterolide (3) is described in this report. Bis(pseudopterane) amine showed selective growth inhibition activity against cancer cell lines with IC(50) values of 4.2 microM (HCT116) and 42 microM (HeLa).
DOI 10.1021/np8008144
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