Conduction block in one-dimensional heart fibers
|Title||Conduction block in one-dimensional heart fibers|
|Author(s)||Jeffrey J. Fox, Robert F.,,Jr Gilmour, Eberhard Bodenschatz|
|Journal||Physical Review Letters|
|Abstract||We present a nonlinear dynamical systems analysis of the transition to conduction block in one-dimensional cardiac fibers. We study a simple model of wave propagation in heart tissue that depends only on the recovery of action potential duration and conduction velocity. If the recovery function has slope >or=1 and the velocity recovery function is nonconstant, rapid activation causes dynamical heterogeneity and finally conduction block away from the activation site. This dynamical mechanism may play a role in the initiation and breakup of spiral waves in excitable media.|
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