Conduction block in one-dimensional heart fibers



Title Conduction block in one-dimensional heart fibers
Author(s) Jeffrey J. Fox, Robert F.,,Jr Gilmour, Eberhard Bodenschatz
Journal Physical Review Letters
Date 2002
Volume 89
Issue 19
Start page 198101
End page 198101
Abstract We present a nonlinear dynamical systems analysis of the transition to conduction block in one-dimensional cardiac fibers. We study a simple model of wave propagation in heart tissue that depends only on the recovery of action potential duration and conduction velocity. If the recovery function has slope >or=1 and the velocity recovery function is nonconstant, rapid activation causes dynamical heterogeneity and finally conduction block away from the activation site. This dynamical mechanism may play a role in the initiation and breakup of spiral waves in excitable media.
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