Boundary-induced reentry in homogeneous excitable tissue



Title Boundary-induced reentry in homogeneous excitable tissue
Author(s) Fernando Siso-Nadal, Niels F. Otani, Robert F.,,Jr Gilmour, Jeffrey J. Fox
Journal Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Date 2008
Volume 78
Issue 3
Start page 031925
End page 031925
Abstract Heterogeneity of cardiac electrical properties can lead to heart rhythm disorders. Numerical studies have shown that stimuli chosen to maximize dynamic heterogeneity terminate wave propagation. However, experimental investigations suggest that similar sequences induce fragmentation of the wave fronts, rather than complete wave block. In this paper we show that an insulating boundary in an otherwise homogeneous medium can disrupt dynamically induced wave block by breaking a symmetry in the spatial pattern of action potential duration, leading to unidirectional block and reentrant activation.
DOI 10.1103/physreve.78.031925
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