Intercalation, delivery, and expression of the gene ...

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Title Intercalation, delivery, and expression of the gene encoding green fluorescence protein utilizing nanobiohybrids
Author(s) Katherine M. Tyner, Mark S. Roberson, Kathie A. Berghorn, Li Li, Robert F.,,Jr Gilmour, Carl A. Batt, Emmanuel P. Giannelis
Journal Journal of Controlled Release: Official Journal of the Controlled Release Society
Date 2004
Volume 100
Issue 3
Start page 399
End page 409
Abstract Non-viral gene vectors have attracted much attention recently due to setbacks with viral delivery systems. Here a new non-viral delivery system based on nanobiohybrids synthesized by the intercalation of a full gene and promoter encoding Green Fluorescent Protein (GFP) between the layers of an inorganic host is reported. The nanobiohybrids were delivered to 9L glioma cells, JEG3 choriocarcinoma placental cells, and cardiac myocytes. All cells were able to internalize and tolerate the nanobiohybrids. In addition, all cells expressed the gene with some cell lines having up to 90% transfection efficiency. This new, bio-mimetic delivery system shows promise for use in non-viral gene therapy.
DOI 10.1016/j.jconrel.2004.07.035

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