Chemical screening method for the rapid ...



Title Chemical screening method for the rapid identification of microbial sources of marine invertebrate-associated metabolites
Author(s) Fabrice Berrue, Sydnor T. Withers, Brad Haltli, Jo Withers, Russell G. Kerr
Journal Marine Drugs
Date 2011
Volume 9
Issue 3
Start page 369
End page 381
Abstract Marine invertebrates have proven to be a rich source of secondary metabolites. The growing recognition that marine microorganisms associated with invertebrate hosts are involved in the biosynthesis of secondary metabolites offers new alternatives for the discovery and development of marine natural products. However, the discovery of microorganisms producing secondary metabolites previously attributed to an invertebrate host poses a significant challenge. This study describes an efficient chemical screening method utilizing a 96-well plate-based bacterial cultivation strategy to identify and isolate microbial producers of marine invertebrate-associated metabolites.
DOI 10.3390/md9030369 ER
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