Cranberry (Vaccinium macrocarpon) flavonoids inhibit ...

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Title Cranberry (Vaccinium macrocarpon) flavonoids inhibit matrix metalloproteinases (MMPs) in human prostate cancer cells
Author(s) Malcolm Adam MacLean, Michael David Matchett, Jon Amoroso, Catherine Neto, Robert Hurta
Journal FASEB Journal
Date 2007
Volume 21
Issue 6
Start page A1000
Abstract Blueberry (Vaccinium angustifolium) flavonoid-containing fractions have been shown to inhibit MMP activity (MMP-2/-9) in DU145 prostate cancer cells. This study examined the effect of a whole cranberry extract on MMP activity in DU145 cells. MMP-2/-9 activity was inhibited by this cranberry extract in a dose/time dependent manner. The effect of cranberry extract treatment on TIMP-1/2 was also examined. TIMP-1 protein levels increased in response to 1.0 mg/mI cranberry extract at 6 & 24h of treatment. TIMP-2 protein levels increase when cells were treated with 0.1 mg/ml cranberry extract for 6h. RECK protein levels decrease in a dose dependent manner in response to cranberry. EMMPRIN protein levels decrease when cells were treated with 0.1 mg/ml cranberry extract for 6h and continue to decrease in response to increasing concentrations of cranberry extract. EMMPRIN protein levels decrease in a dose dependent manner when cells were treated with blueberry extract (24h). RECK protein levels apparently decrease in a dose-dependent manner following 24h treatment with whole blueberry extract. This study suggests that cranberry (and blueberry) flavonoid-containing extracts have the ability to modulate MMP-2/-9 activity in DU145 cells and to also affect the expression of a number of activities linked to MMP expression in cells.

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