Capsaicin pretreatment modifies hydrogen ...
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Citation
| Title | Capsaicin pretreatment modifies hydrogen sulphide-induced pulmonary injury in rats |
| Author(s) | M. Prior, F. Green, A. Lopez, A. Balu, G. De Sanctis, G. Fick |
| Journal | Toxicologic Pathology |
| Date | 1990 |
| Volume | 18 |
| Issue | 2 |
| Start page | 279 |
| End page | 288 |
| Abstract | One of the major target organs of hydrogen sulphide gas is the lung. Exfoliation of upper respiratory epithelia and pulmonary edema are prominent effects. Various neuropeptides contained in afferent C-fibres are intimately associated with the epithelia of the conducting airways and are liberated upon exposure to noxious gases. We sought to determine their role in the pathogenesis of hydrogen-sulphide-induced pulmonary injury by pretreating rats with the neurotoxin, capsaicin, which is known to ablate a subpopulation of vagal afferent C-fibres. Groups of capsaicin and saline (control) pretreated Fischer 344 rats were exposed to an edemogenic concentration of hydrogen sulphide (525-559 mg/m3) for 4 hr. Mortality was significantly greater (p less than 0.01) in the capsaicin treated rats (12/12) compared to the control animals (2/12). Pulmonary injury was also more severe in the capsaicin pretreated animals as assessed by lung water content, histological grade of pulmonary edema and protein in the broncho-alveolar fluid. Animals depleted of substance P exhibited a significantly greater (p less than 0.01) degree of bronchial epithelial cell exfoliation and ulceration following exposure to hydrogen sulphide. These experiments indicate that capsaicin sensitive sensory nerves may play a major role in pulmonary defense against the effects of inhaled toxic gases such as hydrogen sulphide. |
| ISSN | 0192-6233 |
Using APA 6th Edition citation style.
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