Altered pre-pulse inhibition in adult rats treated ...



Title Altered pre-pulse inhibition in adult rats treated neonatally with domoic acid
Author(s) A. L. Adams, Tracy A. Doucette, Catherine L. Ryan
Journal Amino Acids
Date 2008
Volume 35
Issue 1
Start page 157
End page 160
Abstract Altered functioning of the glutamate system during critical periods of development is believed to play a role in various neurodevelopmental disorders, such as schizophrenia. Prepulse inhibition (PPI) of the acoustic startle response is deficient in people with schizophrenia. This study investigated the theory that neonatal treatment with domoic acid (DOM), a glutamate agonist, leads to deficient PPI. Results indicate that neonatal treatment with DOM leads to lowered PPI in adult males and an increased startle response in adult females.

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