Low dose domoic acid in neonatal rats abolishes ...



Title Low dose domoic acid in neonatal rats abolishes nicotine induced conditioned place preference during late adolescence
Author(s) M. A. Burt, Catherine L. Ryan, Tracy A. Doucette
Journal Amino Acids
Date 2008
Volume 35
Issue 1
Start page 247
End page 249
Abstract In this study, neonatal rats were chronically exposed to low, non-convulsive doses of the kainate receptor agonist domoic acid (DOM), or saline. Later, as adolescents, all animals were tested in a nicotine-induced conditioned place preference (CPP) paradigm. As expected, a nicotine-induced CPP was evident in the adolescent control rats, but surprisingly, not in the DOM animals. This study demonstrates the importance of KA receptors in the development of normal adolescent behaviors manifested in response to the rewarding properties of nicotine.

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