Tracheal versus pulmonary deposition and clearance ...



Title Tracheal versus pulmonary deposition and clearance of inhaled Pasteurella haemolytica or Staphylococcus aureus in mice
Author(s) L. M. Rodriguez, Alfonso Lopez
Journal Canadian Journal of Comparative Medicine
Date 1985
Volume 49
Issue 3
Start page 323
End page 326
Abstract The aim of this investigation was to do a comparative study on the deposition and clearance of inhaled bacteria between the lungs and tracheae of mice exposed to aerosols of bacteria. Mice were divided into 4 groups of 72 each and exposed to aerosols of P. haemolytica or S. aureus in 4 replicates. The numbers of bacteria were determined in the trachea and lungs of mice sacrificed 0, 2, 4, 8 12, 24, 48 and 72 h postexposure. Results indicated that bacterial deposition was greater in lungs than in tracheae. No significant (P > 0.05) difference was observed between P. haemolytica and S. aureus clearance rates. Although bacteria were rapidly eliminated from the whole respiratory tract, bacterial clearance was significantly (P < 0.002) faster in tracheae than lungs. A significant (P < 0.05) replicate effect was also observed.

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