Development of an effective whole-spore vaccine to ...

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Title Development of an effective whole-spore vaccine to protect against microsporidial gill disease in rainbow trout (Oncorhynchus mykiss) by using a low-virulence strain of Loma salmonae
Author(s) D. J. Speare, R. J. F. Markham, N. J. Guselle
Journal Clinical and Vaccine Immunology
Date 2007
Volume 14
Issue 12
Start page 1652
End page 1654
Abstract In determining the effective vaccine spore dose of a low-virulence strain of Loma salmonae to limit micro-sporidial gill disease in trout, we found that fish receiving 10(3) to 10(5) killed spores had the best protection against experimental infection, with 85% fewer xenomas in their gills than in the controls. Intraperitoneal delivery of the vaccine was effective, and the addition of adjuvant did not improve vaccine performance against this disease-causing microsporidian.
DOI 10.1128/CVI.00365-07

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