Evidence that substance P may be a modulator rather ...
|Title||Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation|
|Author(s)||M. Sweeney-Nixon, J. Sawynok|
|Journal||Canadian Journal of Physiology and Pharmacology|
|Abstract||Substance P (SP), injected intrathecally, produced a dose-related increase in responsiveness (hyperalgesia) in a pressure test for nociceptive thresholds. Pretreatment with two doses of SP produced complete desensitization to this response but did not alter base-line responsiveness. The hyperalgesic response to SP and the lack of change in base line following desensitization to SP suggest a modulator rather than a transmitter role for SP in the transmission of noxious mechanical stimulation.|
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