Prenatal exposure to antiadrenergic antihypertensive ...



Title Prenatal exposure to antiadrenergic antihypertensive drugs: effects on neurobehavioral development and the behavioral consequences of enriched rearing
Author(s) Catherine L. Ryan, Bruce A. Pappas
Journal Neurotoxicology and Teratology
Date 1990
Volume 12
Start page 359
End page 366
Abstract Administered one of the beta blockers propranolol (5 or 20 mg/kg) or atenolol (5 or 20 mg/kg) or the alpha-2 agonist clonidine (20 or 100 ?g/kg) in the drinking water to pregnant rats over Gestation Days 1-21. Prenatal exposure to the drugs did not alter the beneficial effects of enriched rearing on maze solving. However, clonidine-exposed (100 ?g/kg) female rats that were raised in enrichment showed a significantly increased mortality rate.

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