Anaphylactoid reactions to Mellavax [Salmonella ...

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Title Anaphylactoid reactions to Mellavax [Salmonella dublin vaccine] in calves
Author(s) John F. Burka, J. Scarnell
Journal Veterinary Record
Date 1978
Volume 102
Issue 22
Start page 483
End page 484
Abstract Mellavax (avirulent S. dublin vaccine) appears to cause an anaphylactoid reaction in a ratio of 1:28 000 doses sold. A clinical picture of respiratory embarrassment and pulmonary oedema occurs. Histamine, 5-HT and dopamine are implicated mediators released during the reaction but to a minor extent compared with prostaglandins, which appear to play a major role in calves. Sodium meclofenamate, aspirin and indomethacin protect calves during acute systemic anaphylaxis and should be used in addition to adrenalin..

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