Chemical mediators of anaphylaxis (histamine, 5-HT ...

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Title Chemical mediators of anaphylaxis (histamine, 5-HT and SRS-A) released from horse lung and leukocytes in vitro
Author(s) John F. Burka, T. R. Deline, M. C. Holroyde, P. Eyre
Journal Research Communications in Chemical Pathology and Pharmacology
Date 1976
Volume 13
Issue 3
Start page 379
End page 388
Abstract Horses were sensitized to bovine plasma in Freund's complete adjuvant. Leucocytes from venous blood of sensitized horses yielded histamine on incubation with bovine plasma. Isolated lung fragments from horses, on incubation with bovine plasma yielded histamine and 5-HT but not slow-reacting substance of anaphylaxis (SRS-A). Pulmonary veins from the same animals contracted in response to histamine, 5-HT and to antigen (Schultz-Dale reaction). Histamine and 5-HT probably contribute to immediate-type hypersensitivity in horses, whereas the role of SRS-A is not known..

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