The role of immunostimulation in the development of ...

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Title The role of immunostimulation in the development of postweaning multisystemic wasting syndrome in pigs under field conditions
Author(s) J. Haruna, Paul E. Hanna, Daniel Hurnik, B. O. Ikede, Lisa M. Miller, Carmencita V. Yason
Journal Canadian Journal of Veterinary Research. Revue Canadienne de Recherche Veterinaire
Date 2006
Volume 70
Issue 4
Start page 269
End page 276
Abstract We evaluated the effects of immunostimulation in the development of postweaning multisystemic wasting syndrome (PMWS) in 930 pigs 53 to 54 d old in a grower/finisher barn with a history of PMWS. The pigs were allocated to 5 treatment groups: 4 groups received a single intramuscular injection of RespiSure-ONE (a commercial Mycoplasma hyopneumoniae vaccine; n = 197), Emulsigen (an oil-based adjuvant; n = 172), Alhydrogel (an aluminum-hydroxide-based adjuvant; n = 172), or physiologic saline (n = 218); 1 group received no treatment (n = 171). Pigs affected by PMWS were found in all the groups. Antigen to Porcine circovirus type 2 (PCV-2) was detected by immunohistochemical testing within lesions of mesenteric lymph node, spleen, Peyer's patch, and lung of affected pigs. There was no significant difference in the incidence of PMWS among the groups. The findings indicate that immunostimulation did not influence the expression of PMWS in this study. Thus, routine vaccination against swine diseases may not significantly contribute to the occurrence of PMWS under field conditions.

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