Persistent hyperammonemia in two related Morgan ...



Title Persistent hyperammonemia in two related Morgan weanlings
Author(s) R. S. McCornico, Wendy M. Duckett, P. A. Wood
Journal Journal of Veterinary Internal Medicine / American College of Veterinary Internal Medicine
Date 1997
Volume 11
Issue 4
Start page 264
End page 266
Abstract Persistent hyperammonemia was diagnosed in 2 Morgan fillies with clinical signs that developed early in the postweaning period. Diagnostic evaluation, including routine serum chemistries, CBC, liver biopsy, hepatic ultrasonography, liver function test, and necropsy findings did not support a toxic, developmental, or infectious cause. Abnormal serum amino acid and urine orotic acid concentrations suggest that the foals may have had an inherited disorders described in humans as hyperornithinemia, hyperammonemia, and homocitrullinuria (HHH) syndrome. The disorder is thought to be caused by a defective mitochondrial transporter protein, such that ornithine, required for complete urea synthesis, is deficient, thus causing increases in blood ammonia and ornithine concentrations.

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