Evidence for lipoxygenase pathway involvement in ...
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Citation
| Title | Evidence for lipoxygenase pathway involvement in allergic tracheal contraction |
| Author(s) | J. Burka, N. Paterson |
| Journal | Prostaglandins |
| Date | 1980 |
| Volume | 19 |
| Issue | 4 |
| Start page | 499 |
| End page | 515 |
| Abstract | Challenge of actively sensitized guinea-pig trachea in vitro led to a contraction which was enhanced by the cyclo-oxygenase inhibitors, indomethacin and sodium meclofenamate. Cyclo-oxygenase inhibitors eliminated the release of PGE-like material induced by arachidonic acid (AA), histamine, and antigen challenge. AA (10 microgram./ml.) and PGE2 (100 ng./ml.) usually relaxed the trachea, whereas in the presence of cyclo-oxygenase inhibitors a contraction occurred. Phenidone and ETYA, which also blocked the lipoxygenase pathway of AA metabolism inhibited the enhancement of allergic tracheal contraction induced by cyclo-oxygenase inhibitors, decreased the time that the trachea remained contracted, and also eliminated the contraction induced by AA and PGE2. Thus, cyclo-oxygenase inhibitors may enhance allergic tracheal contraction by diverting AA metabolism into the lipoxygenase pathway and product of the latter pathway, possibly SRS-A, may be responsible for the enhancement and for the prolonged phase of allergic tracheal contraction. An analogous mechanism may account for aspirin-induced asthma in man. |
| ISSN | 0090-6980 |
Using APA 6th Edition citation style.
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