An acute hemolytic transfusion reaction caused by ...

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Title An acute hemolytic transfusion reaction caused by dog erythrocyte antigen-1.1 incompatibility in a previously sensitized dog
Author(s) U. Giger, Hans C. J. Gelens, M. B. Callan, D. A. Oakley
Journal Journal of the American Veterinary Medical Association
Date 1995
Volume 206
Issue 9
Start page 1358
End page 1362
Abstract An acute hemolytic transfusion reaction resulting from dog erythrocyte antigen (DEA) 1.1 incompatibility developed in a dog previously sensitized to DEA 1.1 by a transfusion 3 years earlier. The dog developed fever, pigmenturia, and lethargy, and its pcv did not rise as expected. The donor blood was type DEA 1.1 positive, whereas the recipient's blood was type DEA 1.1, DEA 1.2, and DEA 7 negative. A major crossmatch was later found to be strongly incompatible. Studies of the recipient's plasma revealed a specific anti-DEA 1.1 alloantibody of the IgG class with high hemolysin and agglutinin activity. Such acute hemolytic transfusion reactions can be avoided by crossmatching previously transfused dogs and by using dogs that are type DEA 1.1 negative (and preferably also type DEA 1.2 and DEA 7 negative) as blood donors.-U. Giger et al (J Am Vet Med Assoc 1995;206:1358-1362). Key words: canine species; blood type; transfusion reaction.

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