Effect of volume variations on osteogenic ...

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Title Effect of volume variations on osteogenic capabilities of autogenous cancellous bone graft in dogs
Author(s) W. J. DeVries, Caroline L. Runyon, S. A. Martinez, W. P. Ireland
Journal American Journal of Veterinary Research
Date 1996
Volume 57
Issue 10
Start page 1501
End page 1505
Abstract OBJECTIVE: To evaluate the osteogenic effect of differing volumes of autogenous cancellous bone graft (ACBG) placed into partial cortical defects of the ulna. ANIMALS: 15 healthy, mature Beagles. PROCEDURE: Weekly radiographic views of defects were obtained over 8 weeks and were analyzed for bone density by use of radiographic optical densitometry. Histologic sections were obtained 8 weeks after surgery and were planimetrically evaluated for area of total, lamellar, and woven bone. RESULTS: Defects receiving 0.3 and 0.75 g of ACBG had rapid initial bone production, and dogs receiving 0.3 g of ACBG had faster bone ingrowth than did those receiving 0.1 g of ACBG or controls. Defects receiving 0.75 g of ACBG had a rate of bony ingrowth equal to 0.3 g of ACBG. There was no difference in the histomorphometric area fractions of total, lamellar, or woven bone between defects treated with 0.1 or 0.75 g of ACBG, and between grafted or control defects, 8 weeks after surgery. CONCLUSIONS: Overfilling a cortical defect with ACBG does not enhance early osteogenesis within the defect, and underfilling will delay the onset of osteogenesis within the defect. CLINICAL RELEVANCE: A volume of ACBG sufficient only to fill a cortical defect is required to obtain a clinical osteogenic effect from the graft.
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