Characteristics of the labile neurotoxin associated ...



Title Characteristics of the labile neurotoxin associated with nervous coccidiosis
Author(s) C. M. Isler, James E. C. Bellamy, G. A. Wobeser
Journal Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Veterinaire
Date 1987
Volume 51
Issue 2
Start page 271
End page 276
Abstract Reported are the results of preliminary attempts to characterize the molecular weight, heat sensitivity and other features of a labile neurotoxin identified in the serum of calves exhibiting neurological signs in association with coccidial enteritis. The labile neurotoxin activity is heat labile (60 degrees C for 30 min) and is lost upon exposure to acidic pH (5.5) and cysteine (1.75 g/100 mL serum). Activity can be recovered from the precipitate of a 30% wt/vol solution of (NH4)2SO4 in serum. Ultrafiltration trials suggest that labile neurotoxin activity may be linked to a molecule of over 300,000 MW.

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