Characteristics of the labile neurotoxin associated ...

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Title Characteristics of the labile neurotoxin associated with nervous coccidiosis
Author(s) C. M. Isler, James E. C. Bellamy, G. A. Wobeser
Journal Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Veterinaire
Date 1987
Volume 51
Issue 2
Start page 271
End page 276
Abstract Reported are the results of preliminary attempts to characterize the molecular weight, heat sensitivity and other features of a labile neurotoxin identified in the serum of calves exhibiting neurological signs in association with coccidial enteritis. The labile neurotoxin activity is heat labile (60 degrees C for 30 min) and is lost upon exposure to acidic pH (5.5) and cysteine (1.75 g/100 mL serum). Activity can be recovered from the precipitate of a 30% wt/vol solution of (NH4)2SO4 in serum. Ultrafiltration trials suggest that labile neurotoxin activity may be linked to a molecule of over 300,000 MW.

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