Estimation of antemortem serum electrolytes and urea ...

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Title Estimation of antemortem serum electrolytes and urea concentrations from vitreous humor collected postmortem
Author(s) I. W. Wilkie, James E. C. Bellamy
Journal Canadian Journal of Comparative Medicine. Revue Canadienne de Medecine Comparee
Date 1982
Volume 46
Issue 2
Start page 146
End page 149
Abstract Electrolyte and urea levels of vitreous humor collected from bovine eyes at various times postmortem, were compared with serum levels in the same animals. Provided the vitreous humor was filtered immediately after collection, measured levels of total calcium (Ca), potassium ions (K+), sodium ions (Na+) and urea nitrogen were very consistent. For 24 hours postmortem the concentrations of Ca, Na+ and urea nitrogen remained stable, while K+ increased to approximately 55% more than the immediate postmortem level. A small study using anesthetized dogs indicated that urea nitrogen levels of vitreous humor take several hours to equilibrate with elevated blood levels. Analysis of vitreous humor may be a useful adjunct to diagnosis in cases where antemortem clinical chemistry is absent or inadequate.

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