Endogenous regulation of insulin secretion by UCP2

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Title Endogenous regulation of insulin secretion by UCP2
Author(s) Catherine B. Chan
Journal Clinical Laboratory
Date 2002
Volume 48
Issue 11-12
Start page 599
End page 604
Abstract Uncoupling protein 2 (UCP2) expression is more-or-less ubiquitous, in tissues of diverse function. Its presence in adipose and muscle is postulated to be involved in regulation of energy expenditure and nutrient partitioning, particularly that of fats. In pancreatic islet beta cells, induction of UCP2 is shown to inhibit glucose-stimulated insulin secretion. Thus, insufficient insulin secretion in models of type 2 diabetes is associated with elevated UCP2 expression in islets. The evidence for such a role for UCP2 in the regulation of insulin secretion in islets is reviewed.
PubMed ID 12465744

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