Predictive modelling of post-onset xenoma growth ...
|Title||Predictive modelling of post-onset xenoma growth during microsporidial gill disease (Loma salmonae) of salmonids|
|Author(s)||L. E. Rodriguez-Tovar, David J. Speare, R. J. Frederick Markham, J. Daley|
|Journal||Journal of Comparative Pathology|
|Abstract||Loma salmonae, an obligate intracellular microsporidian parasite, is the causal agent of microsporidial gill disease of salmon (MGDS), characterized by the production, growth and eventual rupture of spore-filled xenomas. MGDS in farmed chinook salmon remains occult until xenoma rupture, at which time the infected fish respond with intense branchitis and high rates of mortality. The present study showed that in experimentally infected fish the rate of change of xenoma diameter could be modelled through regression analysis, particularly through the period of 4-9 weeks post-infection, yielding the predictive equation: xenoma diameter=-42.9 microns +15.3 microns x (number of weeks post-infection). This provides a tool for diagnosticians to predict the time to xenoma rupture and hence to the initiation of the clinical phase of MGDS.|
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