Molecular studies on infectious salmon anaemia virus ...

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Title Molecular studies on infectious salmon anaemia virus (ISAV)
Author(s) Frederick S. B. Kibenge
Journal Bulletin of the Aquaculture Association of Canada
Date 2004
Volume 104
Issue 2
Start page 71
End page 78
Abstract Infectious salmon anaemia (ISA) virus (ISAV) is currently one of the most important viral pathogens threatening commercial aquaculture in the northern hemisphere. The virus is classified in the family Orthomyxoviridae, genus Isavirus. The virus offers a significant challenge to fish biologists interested in diagnosis and control of ISA, and to molecular virologists because of its evolutionary relationship with influenza viruses. Being an orthomyxovirus, ISAV is expected to be prone to genetic and antigenic variation. However, while the ISAV genome, like the influenza A virus genome, encodes at least nine structural proteins, the gene order and putative functional identities of the ISAV proteins are significantly different from those of influenza viruses. Although the virulence of influenza A viruses is a polygenic trait, one virulence factor is correlated with the haemagglutinin cleavage site. It remains to be shown which genetic variations in ISAV are associated with the virulence of the virus. The ability of ISAV to kill rainbow trout is a correlate of ISAV pathogenicity that might facilitate the identification of ISAV virulence genes..

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