Ability of flumazenil, butorphanol, and naloxone to ...

Description

Citation

Title Ability of flumazenil, butorphanol, and naloxone to reverse the anesthetic effects of oxymorphone-diazepam in dogs
Author(s) Kip A. Lemke, W. J. Tranquilli, J. C. Thurmon, G. J. Benson, W. A. Olson
Journal Journal of the American Veterinary Medical Association
Date 1996
Volume 209
Issue 4
Start page 776
End page 779
Abstract Six dogs were randomly assigned to each of 6 reversal treatment groups. At least 7 days were allowed to elapse between experiments in the same dog. In each experiment, oxymorphone (0.22 mg/kg of body weight, i.v.) and diazepam (0.22 mg/kg, i.v.) were given sequentially 15 min after glycopyrrolate (0.01 mg/kg, i.v.) administration. Physiological saline solution (SAL, 1 ml), flumazenil (FLU, 0.01 mg/kg), butorphanol (BUT, 0.44 mg/kg), or naloxone (NAL, 0.06 mg/kg) alone, or FLU-BUT or FLU-NAL (same dosages) was given i.v. as a reversal treatment 15 min after oxymorphone-diazepam administration. An individual unaware of the treatment protocol recorded time to extubation, sternal recumbency, and walking. Time to extubation was significantly less with BUT, NAL, FLU-BUT, or FLU-NAL treatment, compared with that for SAL treatment. Time to sternal recumbency was less with BUT, NAL, FLU-BUT, or FLU-NAL treatment, compared with that for SAL treatment. Time to walking was less with FLU-BUT or FLU-NAL treatment, compared with that for SAL treatment. It is concluded that flumazenil, in combination with butorphanol or naloxone, can be used to reverse the anaesthetic effects of oxymorphone-diazepam in dogs..

Using APA 6th Edition citation style.

[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]

Times viewed: 291

Adding this citation to "My List" will allow you to export this citation in other styles.