Relationship between urine ammonium ion excretion ...

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Title Relationship between urine ammonium ion excretion and urine anion gap in dogs
Author(s) Darcy H. Shaw
Journal American Journal of Veterinary Research
Date 1991
Volume 52
Issue 12
Start page 1956
End page 1959
Abstract Acidaemia stimulates renal ammonia production and excretion. This adaptive response allows increased H+ secretion and generation of new bicarbonate. To determine whether a relationship existed between urine ammonium (NH4+) concentration and excretion and urine anion gap (Na+ + K+ - Cl-), ammonium chloride (NH4Cl) was administered per os for 5 days to induce systemic acidaemia in 12 healthy Beagles. During NH4Cl administration, a strong, relationship was apparent between urine NH4+ concentration measured in millimoles per litre and urine anion gap. A significant relationship existed between urine NH4+ excretion measured in millimoles per kilogram of body weight per day and urine anion gap. As urine NH4+ concentration or excretion increased, the urine anion gap became more negative. Before NH4Cl administration (no systemic acidaemia), a weak, but significant relationship was observed between urine NH4+ concentration and urine anion gap. However, a relationship was not evident between urine NH4+ excretion and urine anion gap before NH4Cl administration. Hence, urine anion gap is a reliable index of urine NH4+ concentration and excretion only in dogs with metabolic acidosis. In human beings with distal renal tubular acidosis, NH4+ excretion is inappropriately low and results in a positive urine anion gap. Therefore, as a reliable index of NH4+ excretion, urine anion gap may represent an easy and rapid method to aid in the diagnosis of distal renal tubular acidosis in dogs..

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