Persistence of serum antibodies to Sarcocystis ...



Title Persistence of serum antibodies to Sarcocystis neurona in horses moved from North America to India
Author(s) C. M. Brown, J. K. Morrow, C. L. Carleton, Balaji Ramanathan, R. Reddy, V. Vaidya, S. M. Karthikeyan, A. A. Zulfikar, V. S. Kannadkar
Journal Journal of Veterinary Internal Medicine / American College of Veterinary Internal Medicine
Date 2006
Volume 20
Issue 4
Start page 994
End page 997
Abstract BACKGROUND: The study reported here was undertaken to assess the presence of antibodies to Sarcocystis neurona in the serum of horses of North American origin that had been relocated for 1 year or more to India (ie, outside of the known endemic areas for S. neurona). HYPOTHESIS: The presence or absence of such antibodies should provide information concerning the persistence of such antibodies, or support the presence of chronic infection, or both. ANIMALS: A total of 228 Thoroughbred horses were sampled in India, of which 86 were of North American origin that had been in India between 1 and 13 years, 124 were Indian-born horses that had never been out of India, 8 were of Irish origin, 8 were of English origin, and 2 were originally from France. METHODS: Sera were tested using established western blot analysis. RESULTS: Of the Indian-born horses, 0.8% were test positive, and of the North American horses, 42% were test positive. All of the English and Irish horses were test negative, and the 2 French horses were test positive. CONCLUSIONS AND CLINICAL IMPORTANCE: These data indicate that antibodies against S. neurona can be detected for many years after horses have been removed from an endemic area and that this may be attributable to long half-life of the antibodies or to chronic infection and ongoing antibody production, or both.

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