Characterization of bovine cDNA encoding triggering ...
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Citation
| Title | Characterization of bovine cDNA encoding triggering receptor expressed on myeloid cells 1 (TREM-1) |
| Author(s) | B. Ramanathan, J. Minton, C. Ross, F. Blecha |
| Journal | Veterinary immunology and immunopathology |
| Date | 2004 |
| Volume | 102 |
| Issue | 1-2 |
| Start page | 85 |
| End page | 89 |
| Abstract | Triggering receptor expressed on myeloid cells 1 (TREM-1) is a type I transmembrane receptor of the immunoglobulin superfamily expressed predominantly on neutrophils and monocytes. TREM-1 induces the expression of inflammatory cytokines and adhesion molecules, and augments osteoclast, microglia, oligodendrocyte, and dendritic cell differentiation. Here, we report the cloning of TREM-1 from bovine bone marrow cells. Full-length bovine TREM-1 cDNA is 1202 base pairs in length and encodes a predicted 232 amino acid peptide. Comparative analyses showed that bovine TREM-1 has 48 to 61% amino acid identity with other TREM-1 proteins, sharing the greatest identity with porcine TREM-1. Cysteine residues characteristic of the immunoglobulin superfamily were conserved in bovine TREM-1 and RT-PCR analysis revealed diverse mRNA tissue expression for bovine TREM-1. Molecular cloning of bovine TREM-1 extends the repertoire of bovine pattern recognition receptors and provides information important for investigating their role in bovine innate immunity. |
| DOI | 10.1016/j.vetimm.2004.05.007 |
| ISSN | 0165-2427 |
Using APA 6th Edition citation style.
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