PR-39, a porcine antimicrobial peptide, inhibits ...



Title PR-39, a porcine antimicrobial peptide, inhibits apoptosis: involvement of caspase-3
Author(s) Balaji Ramanathan, H. Wu, C. R. Ross, F. Blecha
Journal Developmental and Comparative Immunology
Date 2004
Volume 28
Issue 2
Start page 163
End page 169
Abstract The porcine antimicrobial peptide, PR-39, has several activities beyond its function of killing bacteria. Here we report that PR-39 alters macrophage viability by inhibiting apoptosis, which was induced by nutrient depletion, LPS stimulation or camptothecin treatment. This antiapoptotic effect was pronounced resulting in significant reductions in annexin-V binding to externalized phosphatidylserine and was associated with a decrease in caspase-3 activity. These findings suggest that PR-39, a porcine neutrophil-derived antimicrobial peptide, might function in the inflammatory milieu not only to kill bacteria, but also to aid in modulating the viability of inflammatory cells by regulating apoptosis.

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