Facile synthesis of ...



Title Facile synthesis of cis-dichloro-(1,4,7-triazacyclononane) platinum(II) and its screening against human ovarian cancer (SK-OV-3) and leukemia (K-562) cell lines.
Author(s) Robert I. Haines, Aleisha M. Murnaghan
Journal Metal-Based Drugs
Date 2002
Volume 9
Issue 1-2
Start page 61
End page 67
Abstract A simple method for the preparation of cis-dichloro(1,4,7-triazacyclononane)platinum(II), cis-Pt(tacn)Cl2 is presented, together with the results of screening the compound against the K-562 (leukemia) and SK-OV-3 (ovarian) human cancer cell lines. While the compound shows no activity against K-562 cells, there is evidence for some cytotoxicity against SK-OV-3. The compound is much less effective than cisplatin, and its limited solubility restricts the useable concentration range.
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