Facile synthesis of ...
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| Title | Facile synthesis of cis-dichloro-(1,4,7-triazacyclononane) platinum(II) and its screening against human ovarian cancer (SK-OV-3) and leukemia (K-562) cell lines. |
| Author(s) | R. Haines, A. Murnaghan |
| Journal | Metal-Based Drugs |
| Date | 2002 |
| Volume | 9 |
| Issue | 1-2 |
| Start page | 61 |
| End page | 67 |
| Abstract | A simple method for the preparation of cis-dichloro(1,4,7-triazacyclononane)platinum(II), cis-Pt(tacn)Cl2 is presented, together with the results of screening the compound against the K-562 (leukemia) and SK-OV-3 (ovarian) human cancer cell lines. While the compound shows no activity against K-562 cells, there is evidence for some cytotoxicity against SK-OV-3. The compound is much less effective than cisplatin, and its limited solubility restricts the useable concentration range. |
| ISSN | 0793-0291 |
| Use/Reproduction | Contact Publisher |
| Text | http://www.islandscholar.ca/download_ds/ir:ir-batch6-4888/PDF |
Using APA 6th Edition citation style.
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