The in vitro immunosuppressive effects of ...



Title The in vitro immunosuppressive effects of moclobemide in healthy volunteers
Author(s) Aihua Lin, Cai Song, G? Kenis, Eugene Bosmans, Raf De Jongh, Simon Scharp?, Michael Maes
Journal Journal of Affective Disorders
Date 2000
Volume 58
Issue 1
Start page 69
End page 74
Abstract Examined, in 9 normal volunteers (mean age 33.1 yrs), the in vitro effects of moclobemide on the production of interleukin-6 (IL-6), IL-8, tumor necrosis factor-? (TNF?), interferon-? (IFN?), IL-10 and the IL-1 receptor antagonist (IL-1RA) by diluted whole blood stimulated or not with lipopolysaccharide (LPS) + phytohemagglutinin. Moclobemide 10-super(-3 ) and 10-super(-5 )significantly suppressed the unstimulated production of TNF? and IL-8, and significantly enhanced the stimulated-production of IL-10. The production of IL-6, IL-1RA and IFN? was not significantly affected either in the unstimulated or stimulated conditions. Mocloberaide has negative immunoregulatory capacities through inhibition of the production of proinflammatory cytokines, i.e. TNF? and IL-8, and through enhancement of the production of IL-10, an anti-inflammatory cytokine.

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