Perturbative diffusion theory formalism for ...

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Title Perturbative diffusion theory formalism for interpreting temporal light intensity changes during laser interstitial thermal therapy
Author(s) Lee C. L. Chin, William M. Whelan, I. Alex Vitkin
Journal Physics in Medicine and Biology
Date 2007
Volume 52
Issue 6
Start page 1659
End page 1674
Abstract In an effort to understand dynamic optical changes during laser interstitial thermal therapy ( LITT), we utilize the perturbative solution of the diffusion equation in heterogeneous media to formulate scattering weight functions for cylindrical line sources. The analysis explicitly shows how changes in detected interstitial light intensity are associated with the extent and location of the volume of thermal coagulation during treatment. Explanations for previously reported increases in optical intensity observed early during laser heating are clarified using the model and demonstrated with experimental measurements in ex vivo bovine liver tissue. This work provides an improved understanding of interstitial optical signal changes during LITT and indicates the sensitivity and potential of interstitial optical monitoring of thermal damage.
DOI 10.1088/0031-9155/52/6/008

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