5-Hydroxytryptamine releases adenosine from primary ...
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Citation
| Title | 5-Hydroxytryptamine releases adenosine from primary afferent nerve terminals in the spinal cord |
| Author(s) | M. Sweeney-Nixon, T. White, J. Sawynok |
| Journal | Brain research |
| Date | 1988 |
| Volume | 462 |
| Issue | 2 |
| Start page | 346 |
| End page | 349 |
| Abstract | 5-Hydroxytryptamine (serotonin, 5-HT) increased the release of endogenous adenosine from dorsal, but not ventral, spinal cord synaptosomes. This release was reduced by (i) the 5-HT receptor antagonist methysergide, (ii) removal of Ca2+ from the medium, (iii) inhibition of ecto-5'-nucleotidase and (iv) capsaicin pretreatment. These data suggest that activation of 5-HT receptors on primary afferent terminals releases a nucleotide which is converted extracellularly to adenosine. This adenosine may contribute to the spinal antinociceptive effect of 5-HT. |
| ISSN | 0006-8993 |
| Use/Reproduction | Contact Author |
Using APA 6th Edition citation style.
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