Different alpha-receptor subtypes are involved in ...
Description
Citation
| Title | Different alpha-receptor subtypes are involved in clonidine-produced analgesia in different pain tests |
| Author(s) | R. Tasker, R. Melzack |
| Journal | Life Sciences |
| Date | 1989 |
| Volume | 44 |
| Issue | 1 |
| Start page | 9 |
| End page | 17 |
| Abstract | Dose-response curves for clonidine-produced analgesia in rats were constructed using the tail-flick and formalin tests. Subsequently, the relative role of alpha 1 and alpha 2 receptors in clonidine analgesia in each of these tests was determined using systemic administration of vehicle controls, tolazoline, yohimbine and prazosin prior to injection of an ED50 dose of clonidine. Clonidine was found to be significantly more potent in the formalin test than in the tail-flick test. Furthermore, clonidine analgesia in the tail-flick test was completely antagonized by tolazoline and yohimbine, but not by prazosin, whereas clonidine was antagonized by tolazoline and prazosin, but not by yohimbine in the formalin test. The implications of these findings with regard to the contributions of different alpha-receptor subtypes to clonidine-produced analgesia in different pain tests are discussed. |
Using APA 6th Edition citation style.
[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]
Times viewed: 67
