Relative cataleptic potency of narcotic analgesics, ...



Title Relative cataleptic potency of narcotic analgesics, including 3,6-dibutanoylmorphine and 6-monoacetylmorphine
Author(s) R. Andrew R. Tasker, P. L. Vander Velden, K. Nakatsu
Journal Progress in Neuro-Psychopharmacology & Biological Psychiatry
Date 1984
Volume 8
Issue 4-6
Start page 747
End page 750
Abstract Dose-response curves were constructed for duration of significant catalepsy in male Sprague-Dawley rats following i.p. administration of four established and two novel narcotic analgesics. The relative potency of the six drugs was levorphanol greater than monacetylmorphine greater than diacetylmorphine greater than dibutanoylmorphine greater than morphine greater than meperidine. Cataleptic potency correlated with analgesic potency for morphine, diacetylmorphine, and dibutanoylmorphine but not for monoacetylmorphine.

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