Effects of melatonin and propranolol on sleep of the rat

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Title Effects of melatonin and propranolol on sleep of the rat
Author(s) W. B. Mendelson, J. C. Gillin, Susan D. Dawson, A. J. Lewy, R. J. Wyatt
Journal Brain Research
Date 1980
Volume 201
Issue 1
Start page 240
End page 244
Abstract Melatonin and L-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. L-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. L-propranolol produced decreased in percentage REM sleep at both times.

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