The role of dopaminergic neurodegeneration in equine ...

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Paper title The role of dopaminergic neurodegeneration in equine pituitary pars intermedia dysfunction (equine Cushing's disease)
Paper author(s) D. McFarlane, M. T. Donaldson, Tarek M. Saleh, Alastair E. Cribb
Proceedings title Proceedings of the 49th Annual Convention of the American Association of Equine Practitioners, New Orleans, Louisiana, USA, 21-25 November 2003
Date 2003
Abstract The objective of this study is to demonstrate the role of oxidative stress and dopaminergic neurodegeneration in the development of equine pituitary pars intermedia dysfunction (PPID). The results support the hypothesis that PPID is a dopaminergic neurodegenerative disease. Horses with PPID had 5 times less tyrosine hydroxylase staining, indicating five-fold reduction in the number of dopaminergic terminals in the pars intermedia..

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