Synthesis and biological evaluation of benzothiazole ...
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| Title | Synthesis and biological evaluation of benzothiazole derivatives of pyrimidines, acrylonitriles, and coumarins. |
| Author(s) | A. Youssef, H. Mohamed, C. Czezowski, A. Ata, A. Abd-El-Aziz |
| Journal | Section Title: Heterocyclic Compounds (More Than One Hetero Atom), Heterocycles |
| Date | 2006 |
| Volume | 68 |
| Issue | 2 |
| Start page | 347 |
| End page | 355 |
| Abstract | A no. of 2-(benzothiazol-2-ylamino)pyrimidines, 2-benzothiazol-2-yl-3-arylacrylonitriles, and benzothiazol-2-ylcoumarins were synthesized by reacting benzothiazole derivs. with dicarbonyl compds. and arom. aldehydes. The unexpected 2-(4-methoxyphenyl)benzo[d]thiazole was obtained as a unique product via the reaction of 2-aminothiophenol with Et 3-(4-methoxyphenyl)-2-cyanoacrylate. 2-(Benzo[d]thiazol-2-yl)-3-(4-hydroxyphenyl)acrylonitrile exhibited activity against Staphylococcus aureus. 2-(Benzo[d]thiazol-2-ylamino)pyrimidine-4,6-(1H,5H)-dione showed antibacterial activity selectivity against Corynebacterium xerosis. 2-(Benzo[d]thiazol-2-ylamino)-6-methylpyrimidin-4(3H)-one showed weak antifungal activity against Candida albicans. [on SciFinder(R)] |
| ISSN | 0385-5414 |
Using APA 6th Edition citation style.
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