The effect of age on serum antibody titers after ...
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| Title | The effect of age on serum antibody titers after rabies and influenza vaccination in healthy horses |
| Author(s) | T. Muirhead, J. McClure, J. Wichtel, H. Stryhn, R. Markham, D. McFarlane, D. Lunn |
| Journal | Journal of Veterinary Internal Medicine |
| Date | 2008 |
| Volume | 22 |
| Issue | 3 |
| Start page | 654 |
| End page | 661 |
| Abstract | Background: The proportion of geriatric horses within the equine population has increased in the past decade, but there is limited information on the immune function of these animals. Hypothesis: Aged horses will have a lesser increase in serum antibody response to vaccination. Animals: Thirty-four aged healthy horses (>= 20 years) and 29 younger adult horses (4-12 years) of various breeds. Methods: All horses were vaccinated with vaccines of killed rabies and influenza virus. Horses in each age group were allocated to receive either rabies or influenza booster vaccine 4 weeks after the initial vaccination. Serum samples were taken at 0, 4, 8, and 24 weeks. Rabies serum neutralization titers and equine influenza virus specific antibody sub-isotypes (IgGa, IgGb, IgG(T), and IgA) as well as single radial hemolysis (SRH) titers were determined. Results: Rabies antibody titers were similar in the 2 age groups at all sampling times. Aged horses had higher IgGa and IgGb influenza antibody titers before vaccination than younger horses but similar titers after vaccination (P = .004 and P = .0027, respectively). Younger horses had significantly greater increases in titer than aged horses at all sampling times for IgGa (P = .001) and at 8 and 24 weeks for IgGb (P = .041 and .01, respectively). There was no detectable serum IgG(T) at any time point. A significant booster vaccine effect was seen for both antirabies and anti-influenza titers. Anti-influenza titer before vaccination also had a significant effect on subsequent antibody response. Conclusions and Clinical Importance: Healthy aged horses generated a primary immune response to a killed rabies vaccine similar to that of younger adult horses. Aged horses had a significantly reduced anamnestic response to influenza vaccine. |
| DOI | 10.1111/j.1939-1676.2008.0091.x |
| ISSN | 0891-6640 |
Using APA 6th Edition citation style.
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