Development of an effective whole-spore vaccine to ...
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| Title | Development of an effective whole-spore vaccine to protect against microsporidial gill disease in rainbow trout (Oncorhynchus mykiss) by using a low-virulence strain of Loma salmonae |
| Author(s) | D. Speare, R. Markham, N. Guselle |
| Journal | Clinical and Vaccine Immunology |
| Date | 2007 |
| Volume | 14 |
| Issue | 12 |
| Start page | 1652 |
| End page | 1654 |
| Abstract | In determining the effective vaccine spore dose of a low-virulence strain of Loma salmonae to limit micro-sporidial gill disease in trout, we found that fish receiving 10(3) to 10(5) killed spores had the best protection against experimental infection, with 85% fewer xenomas in their gills than in the controls. Intraperitoneal delivery of the vaccine was effective, and the addition of adjuvant did not improve vaccine performance against this disease-causing microsporidian. |
| DOI | 10.1128/CVI.00365-07 |
Using APA 6th Edition citation style.
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