Inhibition of matrix metalloproteinase activity in ...
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| Title | Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events |
| Author(s) | M. Matchett, S. MacKinnon, M. Sweeney-Nixon, K. Gottschall-Pass, R. Hurta |
| Journal | The Journal of Nutritional Biochemistry |
| Date | 2006 |
| Volume | 17 |
| Issue | 2 |
| Start page | 117 |
| End page | 125 |
| Abstract | Regulation of the matrix metalloproteinases (MMPs) is crucial to regulate extracellular matrix (ECM) proteolysis which is important in metastasis. This study investigated the mechanism(s) by which three flavonoid-enriched fractions from lowbush blueberry (Vaccinium angustifolium) down-regulate MMP activity in DU145 human prostate cancer cells. Metalloproteinase activity was evaluated from cells exposed to "crude," anthocyanin-enriched (AN) and proanthocyanidin-enriched (PAC) fractions. Differential down-regulation of MMPs was observed. The activity of the endogenous tissue inhibitors of metalloproteinases (TIMPs) from these cells was also evaluated. Increases in TIMP-1 and TIMP-2 activity were observed in response to these fractions. The possible involvement of protein kinase C (PKC) and mitogen-activated protein (MAP) kinase pathways in the flavonoid-mediated decreases in MMP activity was observed. These findings indicate that blueberry flavonoids may use multiple mechanisms in down-regulating MMP activity in these cells. |
| DOI | 10.1016/j.jnutbio.2005.05.014 |
| ISSN | 0955-2863 |
| Use/Reproduction | Contact Author |
Using APA 6th Edition citation style.
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