Evidence that substance P may be a modulator rather ...
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Citation
| Title | Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation |
| Author(s) | M. Sweeney-Nixon, J. Sawynok |
| Journal | Canadian Journal of Physiology and Pharmacology |
| Date | 1986 |
| Volume | 64 |
| Issue | 10 |
| Start page | 1324 |
| End page | 1327 |
| Abstract | Substance P (SP), injected intrathecally, produced a dose-related increase in responsiveness (hyperalgesia) in a pressure test for nociceptive thresholds. Pretreatment with two doses of SP produced complete desensitization to this response but did not alter base-line responsiveness. The hyperalgesic response to SP and the lack of change in base line following desensitization to SP suggest a modulator rather than a transmitter role for SP in the transmission of noxious mechanical stimulation. |
| ISSN | 0008-4212 |
| Use/Reproduction | Contact Author |
Using APA 6th Edition citation style.
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