Activity of closantel against experimentally induced ...
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| Title | Activity of closantel against experimentally induced Fascioloides magna infection in sheep |
| Author(s) | B. Stromberg, J. Schlotthauer, B. Seibert, G. Conboy, K. Newcomb |
| Journal | American Journal of Veterinary Research |
| Date | 1985 |
| Volume | 46 |
| Issue | 12 |
| Start page | 2527 |
| End page | 2529 |
| Abstract | The efficacy of closantel against experimentally induced Fascioloides magna infection in sheep was studied. In each of 3 experiments, closantel was administered 8 weeks after the sheep were given (oral inoculation) 100 metacercariae of F magna. In the 1st experiment, closantel was given orally to 5 groups of 6 sheep each at dosages of 0 (nontreated control), 5, 7.5, 10, and 15 mg/kg of body weight. In the 2nd and 3rd experiments, groups of 10 or 12 sheep were treated to confirm the efficacy of the previously determined optimal dosage of 15 mg/kg. An additional group of sheep (n = 10) was used in the 3rd experiment to evaluate the efficacy of closantel given IM at a dosage of 7.5 mg/kg. Closantel given orally at a dosage level of 15 mg/kg was highly effective (94.6% to 97.7%) in reducing F magna burdens. Also, pathologic scores associated with the F magna infection were reduced by 81.3% to 92.6% in sheep given this dosage of closantel. Efficacy of the IM administered dosage of 7.5 mg of drug/kg was equivalent to that of the 15 mg/kg oral dosage. Other than mild, transient lameness of the limbs which were injected with the drug (group 10), side effects were not observed. |
| ISSN | 0002-9645 |
Using APA 6th Edition citation style.
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