Effects of a pathogenic canine herpesvirus on ...
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Citation
| Title | Effects of a pathogenic canine herpesvirus on established thyroid adenoearanoma cell cultures |
| Author(s) | G. Johnson, A. Koestner, O. Kindig, J. Shad duck |
| Journal | Pathologia vet |
| Date | 1969 |
| Volume | 6 |
| Issue | |
| Start page | 289 |
| End page | 308 |
| Abstract | Early lesions in these cultures (3-10 hours after virus inoculation) consisted of nucleolar sweating and disruption; there was loss of RNA from the nucleo-lus and segregation of nueleolar components (demonstrated by electron microscopy). During the middle phase (10-34 hours) three types of eosinophilic intranuclear inclusion appeared; the inclusions seemed to be formed by progressive transformations. Viral antigen was demonstrated in the nucleus by immuno-fluorescent staining, with viral replication observed at the same time by electron microscope. The late phase (34-72 hours) was manifested by cellular degeneration and viral release into the cytoplasm.. |
Using APA 6th Edition citation style.
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