PU.1-mediated transcriptional regulation of ...
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| Title | PU.1-mediated transcriptional regulation of prophenin-2 in primary bone marrow cells |
| Author(s) | B. Ramanathan, J. Minton, C. Ross, F. Blecha |
| Journal | Gene |
| Date | 2005 |
| Volume | 352 |
| Issue | |
| Start page | 1 |
| Abstract | Prophenin-2 (PF-2) is a cathelicidin, 97-amino-acid antimicrobial protein stored in neutrophil secondary granules. PF-2 is expressed specifically in porcine immature myeloid cells; however, little is known about its regulation. In this study, we characterized the 5' regulatory regions of the PF-2 gene to understand the molecular mechanisms regulating its expression. Using bioinformatic approaches, site-directed mutagenesis, and transactivation experiments, we found that the PF-2 gene was regulated by transcription factor PU.1. In addition, PF-2 expression also is regulated by the cytokines GM-CSF and IL-3. Taken together, these results identify cis- and trans-acting factors involved in the regulation of PF-2 and clarify mechanisms of cathelidicin gene regulation. |
| DOI | 10.1016/j.gene.2005.04.011 |
Using APA 6th Edition citation style.
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