Interleukin-1 beta modulates AMPA receptor ...
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Citation
| Title | Interleukin-1 beta modulates AMPA receptor expression and phosphorylation in hippocampal neurons |
| Author(s) | A. Lai, R. Swayze, A. El-Husseini, C. Song |
| Journal | Journal of neuroimmunology |
| Date | 2006 |
| Volume | 175 |
| Issue | 1-2 |
| Start page | 97 |
| End page | 106 |
| Abstract | Interleukin (IL)-1beta is a pro-inflammatory cytokine involved in modulating inflammation and stress responses in the brain. Central administration of IL-1beta impairs both memory functions and long-term potentiation (LTP) induction. However, the molecular events responsible for the downstream effects of IL-1beta are not fully understood. Given the potential regulatory role of IL-1beta in LTP, we assessed whether IL-1beta influences surface expression and phosphorylation of glutamate receptors. We found that IL-1beta, but not IL-10 or tumour necrosis factor (TNF)-alpha, down-regulated the surface expression and Ser831 phosphorylation of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluR1. Agents that block IL-1beta receptor activity abolished these effects. In contrast, no change in the surface expression of the N-methyl-d-aspartate (NMDA) receptor subunit NR1 was observed. The inhibition of NMDA receptor activity or depletion of extracellular calcium blocked IL-1beta effects on GluR1 phosphorylation and surface expression. NMDA-mediated calcium influx was also regulated by IL-1beta. These findings suggest that IL-1beta selectively regulates AMPA receptor phosphorylation and surface expression through extracellular calcium and an unknown mechanism involving NMDA receptor activity. |
| DOI | 10.1016/j.jneuroim.2006.03.001 |
| ISSN | 0165-5728 |
Using APA 6th Edition citation style.
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